10) Mike Tyson is the final opponent of Mike Tyson's Punch-Out!!, whom Little Mac faces in a bout called "The Dream Fight". He is the undefeated, undisputed Heavyweight Champion of the World. During the first 90 seconds of the fight, all of Tyson's attacks can instantly knock the player down.
9) R-type Stage 3. Any boss can pop up at the end of a level; this one is the level. A giant battleship that filled the entire screen back when 4-inch-tall monsters ruled the arcades, this bad boy can fry you with its thrusters, smash you into a wall, or straight shoot you down. Respect.
8) De Rol Le Final Boss of the Caves section of Phantasy Star Online. Seems to resemble a leech, and in Phantasy Star Universe it resembles a barracuda or moray eel.
7) Alma, one of the Five Greater Fiends of Vigoor and younger sister of Rachel from the Series Ninja Gaiden.
6) Nemesis, also called the Pursuer or Chaser (追跡者 Tsuisekisha?), is a fictional character in Capcom's Resident Evil franchise. Nemesis is a bio-organic weapon, created by the Umbrella Corporation as a form of super soldier. Designed as an improvement on Umbrella's previous Tyrant design, Nemesis can use weapons and think independently enough to overcome obstacles to complete its mission. Unleashed in Raccoon City, its orders are to kill all members of the STARS.
5) Gunstar Green: The mind controlled/amnesiac older brother of the twins who now works for the Empire. He controls a giant shapeshifting Mech, the Seven Force from Gunstar Heroes.
4) The End from Metal Gear Solid 3 : Snake Eater was the "Ancient Sniper" of the Cobra Unit; he was over 100 years old when he was defeated by Naked Snake in 1964.
3) Mother Brain (マザーブレイン, Mazā Burein) is a recurring antagonist and boss in the Metroid series. She is a cold and ill-tempered artificial intelligence created by the Chozo, but turned against them when the Space Pirates and Ridley invaded Zebes. Mother Brain saw potential in the pirates and decided that with them helping, she could bring true order to the universe by "resetting everything back to zero". Mother Brain was seen as a main antagonist in Metroid, Super Metroid, and Metroid: Zero Mission. She is also seen in a flashback during Metroid: Other M, and her consciousness was responsible for the events of that game as well. In the Japanese website for Zero Mission, she is given the title Mad Overseer.
2) Psycho Mantis from Metal Gear Solid was a psychic member of FOXHOUND, who assisted in the armed takeover of Shadow Moses Island in 2005. He wore a gas mask to help prevent people's thoughts from "forcing their way into his mind.
1) Sephiroth (セフィロス Sefirosu?) is a fictional character in the role-playing game Final Fantasy VII developed by Square Co. Introduced there as the main antagonist, character designer Tetsuya Nomura wanted his role in the story to be different from the other Final Fantasy villains while his design is intended to contrast directly with that of the main character, Cloud Strife.
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