Canadian actress Rachel McAdams landed her breakout role at the age of 26 when she played "Queen Bee" Regina George in Tina Fey's satirical 2004 film Mean Girls.
Since then she's been in several mainstream movies, playing Amy in The Family Stone and Colee Dunn in The Lucky Ones. more recently she played Irene Adler in the 2009 version of Sherlock Holmes, earning a Saturn Award for best Supporting Actress.
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